New symptoms must have alleviated, defined as a score of 0 (None) or 1 (Mild).Preexisting symptoms that were worse at baseline must have improved at least 1 point from baseline.Time to improvement of cough, fatigue, and muscle/joint pain was defined as the time from the start of treatment to the time when each symptom was alleviated, maintained, or improved, as defined below, for at least 21.5 hours: Participants assessed the severity of 7 influenza-associated symptoms on a 4-point scale (0 = no symptoms to 3 = severe). Time to improvement of the 3 respiratory symptoms was analyzed using KM methods participants who did not experience improvement of symptoms were censored at the last observation time point. Time to improvement of the 3 respiratory symptoms was defined as the time from the start of study treatment to the time when all 3 respiratory symptoms (cough, sore throat, and nasal congestion) were alleviated, maintained, or improved, as defined below, for a duration of at least 21.5 hours: Participants assessed the severity of 7 influenza-associated symptoms on a 4-point scale (from 0 = no symptoms to 3 = severe symptoms). Time to Improvement of the Three Respiratory Symptoms.Time to improvement of the 4 systemic symptoms was analyzed using KM methods participants who did not experience improvement of symptoms were censored at the last observation. New symptoms at baseline must have alleviated, defined as a symptom score of none (0) or mild (1).Preexisting symptoms not worse at baseline must have maintained baseline severity.Preexisting symptoms (cough, fatigue, or muscle/joint pain that existed prior to influenza) that were worse at baseline must have improved at least 1 point from baseline.
Time to improvement of the 4 systemic symptoms was defined as the time between the initiation of study treatment to the time when all 4 systemic symptoms (headache, feverishness or chills, muscle or joint pain, and fatigue) were alleviated, maintained, or improved, as defined below, for a duration of at least 21.5 hours: Why Should I Register and Submit Results?.